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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propranolol

3

IV.a Bronchospasm - Wheezing - Asthma

2
Last update : 12/09/2012
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
More detailed checklist
See also under
Beta-blockers
5

Publications

Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma.
American journal of respiratory and critical care medicine 2013 Jun 15;187;1308-14 2013 Jun 15
Childhood wheeze while taking propranolol for treatment of infantile hemangiomas.
Pediatric pulmonology 2012 Jul;47;713-5 2012 Jul
Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers.
Chest 2005 Mar;127;818-24 2005 Mar
Effect of beta-blockers on ventilatory function in smokers and non smokers.
The Journal of the Association of Physicians of India 1993 Sep;41;573-5 1993 Sep
Beta-blockers in bronchial asthma: effect of propranolol and pindolol on large and small airways.
Thorax 1983 Feb;38;108-12 1983 Feb
Unwanted effects of propranolol.
The American journal of cardiology 1966 Sep;18;463-72 1966 Sep

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