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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Propranolol
3
IV.a
Bronchospasm - Wheezing - Asthma
2
Last update :
12/09/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Beta-blockers
Publications
Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma.
Childhood wheeze while taking propranolol for treatment of infantile hemangiomas.
Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers.
Effect of beta-blockers on ventilatory function in smokers and non smokers.
Beta-blockers in bronchial asthma: effect of propranolol and pindolol on large and small airways.
Unwanted effects of propranolol.