Pneumotox » Drug » Penicillins

Penicillins

5

Last update : 30/10/2018

I.b Pneumonitis (ILD)

1

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1

IV.a Bronchospasm - Wheezing - Asthma

1

IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

1

VI.d Pulmonary vasculitis or capillaritis

1

VII.a Lymphadenopathy (intrathoracic)

1

VIII.a Angioedema (may cause UAO, asphyxia and death)

1

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

5

X.h Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

-

X.m Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

1

X.t Jarisch-Herxheimer reaction

2

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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