Pneumotox » Drug » Antibiotics

Antibiotics

5

Last update : 07/03/2016

I.b Pneumonitis (ILD)

1

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

3

I.e Acute eosinophilic pneumonia (AEP)

2

IV.a Bronchospasm - Wheezing - Asthma

2

IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

2

VIII.a Angioedema (may cause UAO, asphyxia and death)

1

X.a DRES syndrome - DRESS-like reaction

2

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

3

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

1

XI.n Neutropenia, agranulocytosis (w/wo infection/sepsis)

1

XII.c Pericardial effusion (w/wo tamponade)

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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