Pneumotox » Drug » Immunoglobulins, intravenous (IVIG)

Immunoglobulins, intravenous (IVIG)

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Including varied Ig preparations: IVIG, IgA, anti-D, anti-snake venom Ig... See also under antithymocyte globulins

Last update : 16/07/2015

II.a Pulmonary edema, noncardiogenic (NCPE)

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II.b ARDS - Acute lung injury

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II.d Pulmonary edema, cardiogenic

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II.e Transfusion-related acute lung injury (TRALI) (May cause ARDS)

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III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

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IV.a Bronchospasm - Wheezing - Asthma

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V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

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VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

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X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2

X.m Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

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XII.e Takotsubo (stress) cardiomyopathy

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XII.n Cardiovascular collapse - Cardiogenic shock - Hypotension

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Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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