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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Immunoglobulins, intravenous (IVIG)

3

II.e Transfusion-related acute lung injury (TRALI) (May cause ARDS)

3
Last update : 23/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)
5

Publications

Adverse Effects of Immunoglobulin Therapy.
Frontiers in immunology 2018;9;1299 2018
Transfusion-Related Acute Lung Injury After IVIG for Myasthenic Crisis.
Neurocritical care 2015 Oct;23;259-61 2015 Oct
Transfusion-related acute lung injury after transfusion of pooled immune globulin: a case report.
Transfusion 2014 Dec;54;3088-91 2014 Dec
Adverse effects of human immunoglobulin therapy.
Transfusion medicine reviews 2013 Jul;27;171-8 2013 Jul
Transfusion-related acute lung injury after intravenous immunoglobulin treatment in a lung transplant recipient.
Vox sanguinis 2013 Feb;104;175-8 2013 Feb
Transfusion related acute lung injury with intravenous immunoglobulin.
Indian pediatrics 2011 Oct;48;807-8 2011 Oct
Transfusion-related acute lung injury following intravenous anti-D administration in an adolescent.
American journal of hematology 2008 Aug;83;676-8 2008 Aug
[Transfusion related acute lung injury (TRALI): an unrecognised pathology].
Pathologie-biologie 2005 Mar;53;111-5 2005 Mar
Transfusion-related acute lung injury after the infusion of IVIG.
Transfusion 2001 Feb;41;264-8 2001 Feb
Adult respiratory distress syndrome after experimental intravenous gamma-globulin concentrate and monocyte-reactive IgG antibodies.
Lancet (London, England) 1998 Nov 14;352;1601-2 1998 Nov 14
[A rare cause of intra-alveolar hemorrhage: a transfusion-related incident with leukoagglutination due to antigranulocyte antibodies (Trali syndrome)].
La Revue de medecine interne 1998 Jun;19;434-7 1998 Jun

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