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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Immunoglobulins, intravenous (IVIG)

3

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2
Last update : 23/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)
5

Publications

Adverse effects of human immunoglobulin therapy.
Transfusion medicine reviews 2013 Jul;27;171-8 2013 Jul
A new strategy for the prevention of IgA anaphylactic transfusion reactions.
Transfusion 2004 Apr;44;509-11 2004 Apr
[Anaphylactoid reactions to normal immunoglobulins].
Therapie 2002;57;313-5 2002
Side-effects of intravenous immune globulins.
Clinical and experimental immunology 1994 Jul;97 Suppl 1;79-83 1994 Jul
Common variable immunodeficiency: the disorder and treatment.
Mayo Clinic proceedings 1991 Jan;66;83-96 1991 Jan

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