The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.b

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

Publications

Elia D, Marinou A, Chetta A

Life-threatening asthma after heroin inhalation. A case report and a review of the literature.

Acta bio-medica : Atenei Parmensis 2010 Dec;81;63-7 — 2010 Dec — 63-7

Whale CI, Molyneux AW, Ward MJ

Inhaled heroin causing a life-threatening asthma exacerbation and marked peripheral eosinophilia.

British journal of hospital medicine (London, England : 2005) 2007 Jun;68;332-3 — 2007 Jun — 332-3

Levine M, Iliescu ME, Margellos-Anast H, Estarziau M, Ansell DA

The effects of cocaine and heroin use on intubation rates and hospital utilization in patients with acute asthma exacerbations.

Chest 2005 Oct;128;1951-7 — 2005 Oct — 1951-7

Krantz AJ, Hershow RC, Prachand N, Hayden DM, Franklin C, Hryhorczuk DO

Heroin insufflation as a trigger for patients with life-threatening asthma.

Chest 2003 Feb;123;510-7 — 2003 Feb — 510-7