The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIV.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Abadir S, Ipalawatte H, Takher J

A Rare Case of Valsartan-Induced Angioedema.

Cureus 2025 Jun;17;e85623 — 2025 Jun — e85623

Alhowary AA, Odat H, Alali O, Al-Omari A

Intraoperative angioedema induced by angiotensin II receptor blocker: a case report.

Patient safety in surgery 2018;12;27 — 2018 — 27

Soo Hoo GW, Lin HK, Junaid I, Klaustermeyer WB

Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit.

The American journal of medicine 2015 Jul;128;785-9 — 2015 Jul — 785-9

Montoro de Francisco A, García-Luque A, Fernández M, Puerro M

Side effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists: are we facing a new syndrome.

The American journal of cardiology 2012 Nov 15;110;1552-3 — 2012 Nov 15 — 1552-3

Shino M, Takahashi K, Murata T, Iida H, Yasuoka Y, Furuya N

Angiotensin II receptor blocker-induced angioedema in the oral floor and epiglottis.

American journal of otolaryngology 2011 Nov-Dec;32;624-6 — 2011 Nov-Dec — 624-6

Kalra A, Cooley C, Palaniswamy C, Kalra A, Zanotti-Cavazzoni SL

Valsartan-induced angioedema in a patient on angiotensin-converting enzyme inhibitor for years: case report and literature review.

American journal of therapeutics 2012 Nov;19;e189-92 — 2012 Nov — e189-92

Wüthrich B

[Regarding: Shuster C, Reinhart WH, Hartmann K, Kuhn M. Angioma induced by ACE inhibitors and angiotensin II receptor antagonists: analysis of 98 cases].

Schweizerische medizinische Wochenschrift 1999 Jul 03;129;1003-4 — 1999 Jul 03 — 1003-4

Schuster C, Reinhart WH, Hartmann K, Kuhn M

[Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: analysis of 98 cases].

Schweizerische medizinische Wochenschrift 1999 Mar 06;129;362-9 — 1999 Mar 06 — 362-9