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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Even following topical application of ointment (PMID 29573959). Cross-reacting drugs at PMID 7560658, 24388008

Publications

Hadley A, Slaven JE, Krupp NL, Kloepfer KM

Nonsteroidal anti-inflammatory drug hypersensitivity in a pediatric severe asthmatic population.

Pediatric pulmonology. 2023;58(10):2983-2986

Takeuchi Y, Ando T, Ishiguro C, Uyama Y

Risk of Acute Asthma Attacks Associated With Nonsteroidal Anti-inflammatory Drugs: A Self-Controlled Case Series.

Therapeutic innovation & regulatory science. 2017;51(3):332-341

Morales DR, Guthrie B, Lipworth BJ, Jackson C, Donnan PT, Santiago VH

NSAID-exacerbated respiratory disease: a meta-analysis evaluating prevalence, mean provocative dose of aspirin and increased asthma morbidity.

Allergy. 2015;70(7):828-35

Morales DR, Lipworth BJ, Guthrie B, Jackson C, Donnan PT, Santiago VH

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta-analysis of controlled clinical trials.

The Journal of allergy and clinical immunology. 2014;134(1):40-5

Stevenson DD

Aspirin and NSAID sensitivity.

Immunology and allergy clinics of North America. 2004;24(3):491-505, vii

Vally H, Taylor ML, Thompson PJ

The prevalence of aspirin intolerant asthma (AIA) in Australian asthmatic patients.

Thorax. 2002;57(7):569-74

Levy M

Hypersensitivity to pyrazolones.

Thorax. 2000;55 Suppl 2(Suppl 2):S72-4

Hoigné RV, Braunschweig S, Zehnder D, Kuenzi UP, Hess T, Leuenberger P

Drug-induced attack of bronchial asthma in inpatients: a 20-year survey of the Comprehensive Hospital Drug Monitoring Programme on adverse drug reactions, Berne/St. Gallen.

European journal of clinical pharmacology. 1997;53(1):81-2

Figueras A, Capellà D, Castel JM, Laorte JR

Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs. A report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations.

European journal of clinical pharmacology. 1994;47(4):297-303

Ibáñez L, Laporte JR, Carné X

Adverse drug reactions leading to hospital admission.

Drug safety. 1991;6(6):450-9