The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Bronchospasm - Wheezing - Asthma
Even following topical application of ointment (PMID 29573959). Cross-reacting drugs at PMID 7560658, 24388008
Publications
Nonsteroidal anti-inflammatory drug hypersensitivity in a pediatric severe asthmatic population.
Pediatric pulmonology 2023 Oct;58 — 2023 Oct — 2983-2986
Risk of Acute Asthma Attacks Associated With Nonsteroidal Anti-inflammatory Drugs: A Self-Controlled Case Series.
Therapeutic innovation & regulatory science 2017 May;51;332-341 — 2017 May — 332-341
NSAID-exacerbated respiratory disease: a meta-analysis evaluating prevalence, mean provocative dose of aspirin and increased asthma morbidity.
Allergy 2015 Jul;70;828-35 — 2015 Jul — 828-35
Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta-analysis of controlled clinical trials.
The Journal of allergy and clinical immunology 2014 Jul;134;40-5 — 2014 Jul — 40-5
Aspirin and NSAID sensitivity.
Immunology and allergy clinics of North America 2004 Aug;24;491-505, vii — 2004 Aug — 491-505, vii
The prevalence of aspirin intolerant asthma (AIA) in Australian asthmatic patients.
Thorax 2002 Jul;57;569-74 — 2002 Jul — 569-74
Hypersensitivity to pyrazolones.
Thorax 2000 Oct;55 Suppl 2;S72-4 — 2000 Oct — S72-4
Drug-induced attack of bronchial asthma in inpatients: a 20-year survey of the Comprehensive Hospital Drug Monitoring Programme on adverse drug reactions, Berne/St. Gallen.
European journal of clinical pharmacology 1997;53;81-2 — 1997 — 81-2
Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs. A report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations.
European journal of clinical pharmacology 1994;47;297-303 — 1994 — 297-303
Adverse drug reactions leading to hospital admission.
Drug safety 1991 Nov-Dec;6;450-9 — 1991 Nov-Dec — 450-9