The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Risk is increased by coadministration of chemotherapy (PMID 7509329)

Publications

Martín C, Romero S, Sánchez-Payá J, Massuti B, Arriero JM, Hernández L

Bilateral lymphocytic alveolitis: a common reaction after unilateral thoracic irradiation.

The European respiratory journal. 1999;13(4):727-32

Roberts CM, Foulcher E, Zaunders JJ, Bryant DH, Freund J, Cairns D, Penny R, Morgan GW, Breit SN

Radiation pneumonitis: a possible lymphocyte-mediated hypersensitivity reaction.

Annals of internal medicine. 1993;118(9):696-700

Gibson PG, Bryant DH, Morgan GW, Yeates M, Fernandez V, Penny R, Breit SN

Radiation-induced lung injury: a hypersensitivity pneumonitis?

Annals of internal medicine. 1988;109(4):288-91