The Drug-Induced Respiratory Disease Website and App

Angiotensin converting enzyme inhibitors (ACEI)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.ab

Cough (lone)

Publications

Dicpinigaitis P, Satia I, Ferguson N

Falsely Accused? Insufficient Evidence to Conclude that Sitagliptin is a Cause of Chronic Cough.

Lung 2020 Jan 24;; — 2020 Jan 24

Yilmaz ?, Türk M, Baran Ketencio?lu B, Çetinkaya Z, Tutar N, Oymak FS, Gülmez ?, Adkinson NF

The presence of underlying asthma should be investigated in patients diagnosed with ACE inhibitor induced cough.

The clinical respiratory journal 2020 Jan 04;; — 2020 Jan 04

Smith JA, Woodcock A

Chronic Cough.

The New England journal of medicine 2016 Oct 20;375;1544-1551 — 2016 Oct 20 — 1544-1551

Humbert X, Alexandre J, Sassier M, Default A, Gouraud A, Yelehe-Okouma M, Puddu PE, Fedrizzi S

Long delay to onset of ACE inhibitors-induced cough: Reason of difficult diagnosis in primary care?

European journal of internal medicine 2017 Jan;37;e50-e51 — 2017 Jan

Humbert X, Fedrizzi S, Alexandre J, Puddu PE, Coquerel A, Robert JC, Guittet L

Is ACE-inhibitors cough a difficult diagnosis? 1100 general practitioners replies from four countries.

European journal of internal medicine 2016 Jul;32;e17-8 — 2016 Jul

Brugts JJ, Arima H, Remme W, Bertrand M, Ferrari R, Fox K, DiNicolantonio J, MacMahon S, Chalmers J, Zijlstra F, Caliskan K, Simoons ML, Mourad JJ, Boersma E, Akkerhuis KM

The incidence and clinical predictors of ACE-inhibitor induced dry cough by perindopril in 27,492 patients with vascular disease.

International journal of cardiology 2014 Oct 20;176;718-23 — 2014 Oct 20 — 718-23

Dicpinigaitis PV

Thoughts on one thousand chronic cough patients.

Lung 2012 Dec;190;593-6 — 2012 Dec — 593-6

Li YF, Zhu XM, Liu F, Xiao CS, Bian YF, Li H, Cai J, Li RS, Yang XC

Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.

PloS one 2012;7;e37396 — 2012 — e37396

Dicpinigaitis PV

Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines.

Chest 2006 Jan;129;169S-173S — 2006 Jan — 169S-173S

Overlack A

ACE inhibitor-induced cough and bronchospasm. Incidence, mechanisms and management.

Drug safety 1996 Jul;15;72-8 — 1996 Jul — 72-8

Warner NJ, Rush JE

Safety profiles of the angiotensin-converting enzyme inhibitors.

Drugs 1988;35 Suppl 5;89-97 — 1988 — 89-97

Cooper WD, Sheldon D, Brown D, Kimber GR, Isitt VL, Currie WJ

Post-marketing surveillance of enalapril: experience in 11,710 hypertensive patients in general practice.

The Journal of the Royal College of General Practitioners 1987 Aug;37;346-9 — 1987 Aug — 346-9

Just PM

The positive association of cough with angiotensin-converting enzyme inhibitors.

Pharmacotherapy 1989;9;82-7 — 1989 — 82-7

Rodríguez Cuartero A

[Intractable cough from enalapril].

Anales de medicina interna (Madrid, Spain : 1984) 1991 Dec;8;628 — 1991 Dec — 628