The Drug-Induced Respiratory Disease Website and App

Angiotensin converting enzyme inhibitors (ACEI)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Marcus EL, Hush A, Atrash H, Shibli R, Heyman SN

Life-threatening bronchospasm induced by an angiotensin-converting enzyme inhibitor in a chronically ventilated patient: Diagnostic pitfalls and literature review.

Respirology case reports. 2023;11(10):e01224

Yılmaz İ, Türk M, Baran Ketencioğlu B, Çetinkaya Z, Tutar N, Oymak FS, Gülmez İ, Adkinson NF

The presence of underlying asthma should be investigated in patients diagnosed with ACE inhibitor induced cough.

The clinical respiratory journal. 2020;14(4):382-388

Overlack A

ACE inhibitor-induced cough and bronchospasm. Incidence, mechanisms and management.

Drug safety. 1996;15(1):72-8

Inman WH, Wilton L, Pearce G, Mann RD

Angiotensin converting enzyme inhibitors and asthma.

BMJ (Clinical research ed.). 1994;308(6928):593-4

Popa V

Captopril-related (and -induced?) asthma.

The American review of respiratory disease. 1987;136(4):999-1000