The Drug-Induced Respiratory Disease Website and App

Angiotensin converting enzyme inhibitors (ACEI)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.a

Bronchospasm - Wheezing - Asthma

Publications

Marcus EL, Hush A, Atrash H, Shibli R, Heyman SN

Life-threatening bronchospasm induced by an angiotensin-converting enzyme inhibitor in a chronically ventilated patient: Diagnostic pitfalls and literature review.

Respirology case reports 2023 Oct;11;e01224 — 2023 Oct — e01224

Yilmaz ?, Türk M, Baran Ketencio?lu B, Çetinkaya Z, Tutar N, Oymak FS, Gülmez ?, Adkinson NF

The presence of underlying asthma should be investigated in patients diagnosed with ACE inhibitor induced cough.

The clinical respiratory journal 2020 Jan 04;; — 2020 Jan 04

Overlack A

ACE inhibitor-induced cough and bronchospasm. Incidence, mechanisms and management.

Drug safety 1996 Jul;15;72-8 — 1996 Jul — 72-8

Inman WH, Wilton L, Pearce G, Mann RD

Angiotensin converting enzyme inhibitors and asthma.

BMJ (Clinical research ed.) 1994 Feb 26;308;593-4 — 1994 Feb 26 — 593-4

Popa V

Captopril-related (and -induced?) asthma.

The American review of respiratory disease 1987 Oct;136;999-1000 — 1987 Oct — 999-1000