The Drug-Induced Respiratory Disease Website and App

Angiotensin converting enzyme inhibitors (ACEI)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Kupeli E, Ulubay G, Ulasli SS, Kilic D

Cilazapril-induced pleural effusion: A case report and review of the literature.

Annals of thoracic medicine. 2010;5(3):171-3

Benzaquen-Forner H, Dournovo P, Tandjaoui-Lambiotte H, Sullerot A, Mahé C, Bonin A, Camus P, Valeyre D

[Hypoxic eosinophilic pneumonia in two patients treated with ACE inhibitors].

Revue des maladies respiratoires. 1998;15(6):804-10

Watanabe K, Nishimura K, Shiode M, Sekiya M, Ikeda S, Inoue Y, Iwanaga C

Captopril, an angiotensin-converting enzyme inhibitor, induced pulmonary infiltration with eosinophilia.

Internal medicine (Tokyo, Japan). 1996;35(2):142-5

Schatz PL, Mesologites D, Hyun J, Smith GJ, Lahiri B

Captopril-induced hypersensitivity lung disease. An immune-complex-mediated phenomenon.

Chest. 1989;95(3):685-7