The Drug-Induced Respiratory Disease Website and App

Angiotensin converting enzyme inhibitors (ACEI)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD)

Publications

Takakura A, Kubota M, Otani S, Katono K, Yamamoto M, Masuda N

[A case of valsartan-induced pneumonitis with marked elevation of serum KL-6].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2011 Jul;49;523-7 — 2011 Jul — 523-7

Benard A, Melloni B, Gosselin B, Bonnaud F, Wallaert B

Perindopril-associated pneumonitis.

The European respiratory journal 1996 Jun;9;1314-6 — 1996 Jun — 1314-6

Obergassel L, Carlsson J, Tebbe U

[ACE inhibitor-associated interstitial lung infiltrates].

Deutsche medizinische Wochenschrift (1946) 1995 Sep 22;120;1273-7 — 1995 Sep 22 — 1273-7

Kidney JC, O'Halloran DJ, FitzGerald MX

Captopril and lymphocytic alveolitis.

BMJ (Clinical research ed.) 1989 Oct 14;299;981 — 1989 Oct 14 — 981