The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.h

Major/massive hemoptysis

Publications

Mihai AM, Armstrong PJ, Hickey D, Milano MT, Dunne M, Healy K, Thirion P, Heron DE, ElBeltagi N, Armstrong JG

Late Toxicity and Long-Term Local Control in Patients With Ultra-Central Lung Tumours Treated by Intensity-Modulated Radiotherapy-Based Stereotactic Ablative Body Radiotherapy With Homogenous Dose Prescription.

Clinical oncology (Royal College of Radiologists (Great Britain)) 2021 Jun 04;; — 2021 Jun 04

Nishimura S, Takeda A, Sanuki N, Ishikura S, Oku Y, Aoki Y, Kunieda E, Shigematsu N

Toxicities of organs at risk in the mediastinal and hilar regions following stereotactic body radiotherapy for centrally located lung tumors.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2014 Sep;9;1370-6 — 2014 Sep — 1370-6

Karam SD, Horne ZD, Hong RL, McRae D, Duhamel D, Nasr NM

Dose escalation with stereotactic body radiation therapy boost for locally advanced non small cell lung cancer.

Radiation oncology (London, England) 2013 Jul 10;8;179 — 2013 Jul 10 — 179

Lee DS, Kim YS, Yoo IeR, Kang YN, Kim SJ, Oh JK, Kim YK, Wang YP, Park JG, Kang JH, Han DH, Ahn MI, Lee KY

Long-term clinical experience of high-dose ablative lung radiotherapy: high pre-treatment [18F]fluorodeoxyglucose-positron emission tomography maximal standardized uptake value of the primary tumor adversely affects treatment outcome.

Lung cancer (Amsterdam, Netherlands) 2013 May;80;172-8 — 2013 May — 172-8

Peulen H, Karlsson K, Lindberg K, Tullgren O, Baumann P, Lax I, Lewensohn R, Wersäll P

Toxicity after reirradiation of pulmonary tumours with stereotactic body radiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Nov;101;260-6 — 2011 Nov — 260-6