The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.b

Chest pain (acute or subacute), lone or prominent

Focal, en face the radiation beam. May correspond to or denote rib fracture

Publications

Chipko C, Ojwang J, Gharai LR, Deng X, Mukhopadhyay N, Weiss E

Characterization of Chest Wall Toxicity During Long-term Follow Up After Thoracic Stereotactic Body Radiation Therapy.

Practical radiation oncology. 2019;9(3):e338-e346

Murray L, Karakaya E, Hinsley S, Naisbitt M, Lilley J, Snee M, Clarke K, Musunuru HB, Ramasamy S, Turner R, Franks K

Lung stereotactic ablative radiotherapy (SABR): dosimetric considerations for chest wall toxicity.

The British journal of radiology. 2016;89(1058):20150628

Shaikh T, Turaka A

Predictors and management of chest wall toxicity after lung stereotactic body radiotherapy.

Cancer treatment reviews. 2014;40(10):1215-20

Reyngold M, Wu AJ, McLane A, Zhang Z, Hsu M, Stein NF, Zhou Y, Ho AY, Rosenzweig KE, Yorke ED, Rimner A

Toxicity and outcomes of thoracic re-irradiation using stereotactic body radiation therapy (SBRT).

Radiation oncology (London, England). 2013;8:99

Lloyd S, Decker RH, Evans SB

Bone scan findings of chest wall pain syndrome after stereotactic body radiation therapy: implications for the pathophysiology of the syndrome.

Journal of thoracic disease. 2013;5(2):E41-4

Mutter RW, Liu F, Abreu A, Yorke E, Jackson A, Rosenzweig KE

Dose-volume parameters predict for the development of chest wall pain after stereotactic body radiation for lung cancer.

International journal of radiation oncology, biology, physics. 2012;82(5):1783-90