The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIV.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Strassen U, Bas M, Hoffmann TK, Knopf A, Greve J

Treatment of angiotensin receptor blocker-induced angioedema: A case series.

The Laryngoscope 2015 Jul;125;1619-23 — 2015 Jul — 1619-23

Wang S, Bi X, Shan L, Zhou Y

Orolingual angioedema associated with olmesartan use after recombinant tissue plasminogen activator treatment of acute stroke.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2014 Feb;112;177-8 — 2014 Feb — 177-8

Montoro de Francisco A, García-Luque A, Fernández M, Puerro M

Side effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists: are we facing a new syndrome.

The American journal of cardiology 2012 Nov 15;110;1552-3 — 2012 Nov 15 — 1552-3

Vasquez JL, Jaramillo JC, Fernandez C, Enriquez A, Mielgo R

Severe angioedema associated with olmesartan.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2011 Sep;107;285 — 2011 Sep — 285

Nykamp D, Winter EE

Olmesartan medoxomil-induced angioedema.

The Annals of pharmacotherapy 2007 Mar;41;518-20 — 2007 Mar — 518-20