The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Tongue involvement (edema, glossitis, hematoma)
Can be unilateral (PMID 20529395)
Publications
A Rare Case of Unilateral Tongue Edema with Angiotensin Converting Enzyme Inhibitors.
Acta medica portuguesa 2022 May 25;; — 2022 May 25
Macroglossia secondary to lisinopril-induced acute angioedema.
Proceedings (Baylor University. Medical Center) 2019 Jan;32;70-72 — 2019 Jan — 70-72
Potentially lethal ACE-inhibitor-induced angioedema in a child.
Clinical case reports 2015 Jun;3;427-30 — 2015 Jun — 427-30
Angiotensin-converting enzyme inhibitor-induced unilateral tongue angioedema.
The American journal of the medical sciences 2012 Nov;344;416-7 — 2012 Nov — 416-7
Episodic macroglossia as the sole manifestation of angiotensin-converting enzyme inhibitor-induced angioedema.
The Annals of otology, rhinology, and laryngology 2004 Mar;113;223-4 — 2004 Mar — 223-4
[Angioneurotic edema of the tongue, induced by administration of ACE inhibitors].
HNO 1990 Apr;38;143-4 — 1990 Apr — 143-4