The Drug-Induced Respiratory Disease Website and App

Angiotensin converting enzyme inhibitors (ACEI)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.q

Tongue involvement (edema, glossitis, hematoma)

Can be unilateral (PMID 20529395)

Publications

Gil Braga B, Cravo M, Neves P, Pinto F, Mendonça C

A Rare Case of Unilateral Tongue Edema with Angiotensin Converting Enzyme Inhibitors.

Acta medica portuguesa. 2022;35(7-8):588-590

Ducote C, Kesterke MJ, Bhattacharjee R, Read-Fuller A, Reddy LV

Macroglossia secondary to lisinopril-induced acute angioedema.

Proceedings (Baylor University. Medical Center). 2019;32(1):70-72

Bukhari E, Safdar OY, Shalaby M, AlSharif SM, Alsufiany K, Kari JA

Potentially lethal ACE-inhibitor-induced angioedema in a child.

Clinical case reports. 2015;3(6):427-30

Kuhlen JL Jr, Forcucci J

Angiotensin-converting enzyme inhibitor-induced unilateral tongue angioedema.

The American journal of the medical sciences. 2012;344(5):416-7

Elinav E, Rabinowitz Y, Lorberbaum M, Nisanewitz V

Episodic macroglossia as the sole manifestation of angiotensin-converting enzyme inhibitor-induced angioedema.

The Annals of otology, rhinology, and laryngology. 2004;113(3 Pt 1):223-4

Zech J, Tasman A, Maier H

[Angioneurotic edema of the tongue, induced by administration of ACE inhibitors].

HNO. 1990;38(4):143-4