The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIX.o

Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

Publications

MEANS JH, PITTMAN HS

Radiation pneumonitis; clinicopathological exercises.

The New England journal of medicine 1945 Nov 15;233;597-601 — 1945 Nov 15 — 597-601

WRIGHT RR

Interstitial pneumonia; a pathologic concept.

California medicine 1959 Jan;90;14-6 — 1959 Jan — 14-6

Littman P, Davis LW, Nash J, Tefft M, Borns P, Lepanto P

The hazard of acute radiation pneumonitis in children receiving mediastinal radiation.

Cancer 1974 Jun;33;1520-5 — 1974 Jun — 1520-5

Byhardt RW, Abrams R, Almagro U

The association of adult respiratory distress syndrome (ARDS) with thoracic irradiation (RT).

International journal of radiation oncology, biology, physics 1988 Dec;15;1441-6 — 1988 Dec — 1441-6

Braun SR, doPico A, Olson CE, Caldwell W

Low-dose radiation pneumonitis.

Cancer 1975 May;35;1322-4 — 1975 May — 1322-4