The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Severe or catastrophic bronchospasm or asthma attack (can be fatal)
Even following topical application of ointment (PMID 29573959). Cross-reacting drugs at PMID 7560658, 24388008
Publications
Severe life-threatening asthma precipitated by a topical nonsteroidal anti-inflammatory drug.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2018;120(5):535-536
Frequency and clinical characteristics of rapid-onset fatal and near-fatal asthma.
The European respiratory journal. 2002;19(5):846-52
Severe asthmatic reaction to contraindicated anti-inflammatory drug.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 1997;54(2):199-200
Classification of severe asthma exacerbations: a proposal.
The European respiratory journal. 1996;9(9):1775-8
Asthma death induced by ibuprofen.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace. 1995;50(4):276-8
Aspirin-intolerance as a precipitating factor of life-threatening attacks of asthma requiring mechanical ventilation.
The European respiratory journal. 1989;2(2):127-9
Adverse drug reactions leading to hospital admission.
Drug safety. 1991;6(6):450-9