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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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XXIV.d
Veterinary: Pulmonary bleeding (hemoptysis, alveolar hemorrhage)
Last update :
01/01/1970
Causative drugs
3
Brodifacoum
III.a
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.a - Alveolar hemorrhage (AH), diffuse AH (DAH)
III.c
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.c - Hemoptysis
III.m
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.m - Coagulopathy
V.n
V - Pleural and/or pericardial involvement
V.n - Hemopericardium - Bloody pericardial effusion
VI.a
VI - Pulmonary vasculopathies
VI.a - Pulmonary embolism - Venous thrombosis/thromboembolism
VIII.a
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.a - Angioedema (may cause UAO, asphyxia and death)
VIII.b
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.b - Hematoma of/around central airway wall potentially causing UAO
XXIV.d
XXIV - Veterinary medicine
XXIV.d - Veterinary: Pulmonary bleeding (hemoptysis, alveolar hemorrhage)
XXIV.e
XXIV - Veterinary medicine
XXIV.e - Veterinary: Tracheal hemorrhage, stenosis, collapse
1
Snake envenoming
II.b
II - Pulmonary edema - Acute lung injury - ARDS
II.b - ARDS - Acute lung injury
II.q
II - Pulmonary edema - Acute lung injury - ARDS
II.q - Respiratory distress or failure, not otherwise specified
V.e
V - Pleural and/or pericardial involvement
V.e - Hemothorax - Serosanguineous pleural effusion
XXIV.d
XXIV - Veterinary medicine
XXIV.d - Veterinary: Pulmonary bleeding (hemoptysis, alveolar hemorrhage)
1
Superwarfarins (vitamin K super antagonist rodenticides)
III.a
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.a - Alveolar hemorrhage (AH), diffuse AH (DAH)
III.c
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.c - Hemoptysis
III.k
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.k - Epistaxis
III.m
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.m - Coagulopathy
XXIV.d
XXIV - Veterinary medicine
XXIV.d - Veterinary: Pulmonary bleeding (hemoptysis, alveolar hemorrhage)
2
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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