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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Brodifacoum

4

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2
Last update : 14/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anticoagulants, oral (vitamin K antagonists-VKA)
5
Cannabinoids - Cannabinoid receptor agonists (synthetic) (K2, Spice)
5
Rodenticides
4
Superwarfarins (vitamin K super antagonist rodenticides)
4
Warfarin
5

Publications

Brodifacoum poisoning with toxicokinetic data.
Clinical toxicology (Philadelphia, Pa.) 2007;45;487-9 2007
Severe coagulopathy as a consequence of smoking crack cocaine laced with rodenticide.
The New England journal of medicine 2001 Aug 30;345;700-1 2001 Aug 30
Fatal brodifacoum rodenticide poisoning: autopsy and toxicologic findings.
Journal of forensic sciences 1999 Jul;44;851-5 1999 Jul
Superwarfarin poisoning.
Archives of internal medicine 1998 Sep 28;158;1929-32 1998 Sep 28
Brodifacoum intoxication with marijuana smoking.
Archives of pathology & laboratory medicine 1997 Jan;121;67-9 1997 Jan
Diffuse alveolar hemorrhage secondary to superwarfarin ingestion.
Chest 1992 Oct;102;1301-2 1992 Oct

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