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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Excipients-Vehicle-Preservatives (of drugs)

5

VI.e Fat/oil embolism - The FES embolism syndrome

1
Last update : 13/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amiodarone
5
Benzylbenzoate
1
Cremophor
1
Crospovidone
2
Preservatives
2
Ricin (Castor oil)
2
Sesame oil
1
Soybean
1
Talc (inhaled, sniffed, i.v., intrapleural)
3

Publications

Acute respiratory distress following intravenous injection of an oil-steroid solution.
Canadian respiratory journal 2011;18;e59-61 2011
Acute lung injury probably associated with infusion of propofol emulsion.
Anaesthesia 2007 Aug;62;835-7 2007 Aug
Fatal fat embolism following amphotericin B lipid complex injection.
Experimental and molecular pathology 2004 Dec;77;246-8 2004 Dec
Life-threatening adverse event after amphotericin B lipid complex treatment in a patient treated previously with amphotericin B deoxycholate.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998 Apr;26;1016 1998 Apr

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