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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Chemotherapy, antineoplastic
5
I.au
The chemotherapy lung
5
Last update :
08/05/2019
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amrubicin
Anthracyclines
Azacitidine
Bendamustine
Bleomycin
Bortezomib
Busulfan
Capecitabine
Carboplatin
Carmustine (BCNU)
Cetuximab
Chlorozotocin (DCNU)
Cisplatin
Crizotinib
Cyclophosphamide
Cytosine arabinoside - Aracytine - Cytarabine - Ara-C
Decitabine
Docetaxel
Doxorubicin - Adriamycin
Erlotinib
Etoposide
FOLFIRI chemotherapy regimen
FOLFOX chemotherapy regimen
Famotidine
Floxuridine
Fludarabine
Fluorouracil (5-FU)
Fotemustine
Gefitinib
Gemcitabine
Gemtuzumab
Hydroxyurea (hydroxycarbamide)
Ifosfamide
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
Irinotecan
Lomustine (CCNU)
Melphalan
Methotrexate
Mitomycin C
Mitoxantrone
Nitrogen mustard
Nitrosoureas (suffixes '-NU', '-mustine')
Oxaliplatin-based regimens
Paclitaxel
Pemetrexed
Platinum salts
Procarbazine
Raltitrexed
Taxanes
Temozolomide
Teniposide
Topotecan
Trofosfamide
Tyrosine kinase inhibitors (EGFR) TKI
Vinblastine
Vindesine
Vinorelbine
Zinostatin
Publications
Review: diagnosis of chemotherapy lung.
Cytotoxic drug-induced lung disease.