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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Anthracyclines
5
Daunorubicin, doxorubicin, epirubicin, idarubicin
Last update :
10/05/2015
II - Pulmonary edema - Acute lung injury - ARDS
II.d
Pulmonary edema, cardiogenic
1
XII - Cardiovascular involvement / toxicity
XII.a
Left or biventricular dysfunction/failure
2
XII.f
Cardiomyopathy (acute, subacute, chronic)
4
XII.ai
Cardiotoxicity
5
XII.ak
Late left ventricular dysfunction/failure
5
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Doxorubicin - Adriamycin
Epirubicin
Idarubicin
