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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Teniposide
1
Last update :
17/05/2012
I - Interstitial/parenchymal lung disease
I.l
Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)
1
IV - Airway involvement
IV.a
Bronchospasm - Wheezing - Asthma
1
X - Systemic/Distant conditions, syndromes and reactions
X.f
Anaphylaxis-Anaphylactoid reaction (can be fatal)
1
X.g
Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)
1
XV - Pathology
XV.f
Path: Diffuse alveolar damage (DAD-pattern) (see also IL)
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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