Pneumotox » Drug » Cisplatin

Cisplatin

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Last update : 18/04/2012

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

2

VI.f Hemolytic and uremic syndrome (HUS). See also under Xaf

2

IX.f Hiccup

2

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

3

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

2

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

1

XII.ag Bradycardia

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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