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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Chemotherapy, antineoplastic
5
V.ab
Pneumothorax, bilateral
1
Last update :
19/04/2019
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Amrubicin
Anthracyclines
Azacitidine
Bendamustine
Bleomycin
Bortezomib
Busulfan
Capecitabine
Carboplatin
Carmustine (BCNU)
Cetuximab
Chlorozotocin (DCNU)
Cisplatin
Crizotinib
Cyclophosphamide
Cytosine arabinoside - Aracytine - Cytarabine - Ara-C
Decitabine
Docetaxel
Doxorubicin - Adriamycin
Erlotinib
Etoposide
FOLFIRI chemotherapy regimen
FOLFOX chemotherapy regimen
Famotidine
Floxuridine
Fludarabine
Fluorouracil (5-FU)
Fotemustine
Gefitinib
Gemcitabine
Gemtuzumab
Hydroxyurea (hydroxycarbamide)
Ifosfamide
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
Irinotecan
Lomustine (CCNU)
Melphalan
Methotrexate
Mitomycin C
Mitoxantrone
Nitrogen mustard
Nitrosoureas (suffixes '-NU', '-mustine')
Oxaliplatin-based regimens
Paclitaxel
Pemetrexed
Platinum salts
Procarbazine
Raltitrexed
Taxanes
Temozolomide
Teniposide
Topotecan
Trofosfamide
Tyrosine kinase inhibitors (EGFR) TKI
Vinblastine
Vindesine
Vinorelbine
Zinostatin
Publications
Recurrent bilateral spontaneous pneumothorax complicating chemotherapy for metastatic sarcoma.