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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chemotherapy, antineoplastic

5

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

3
Last update : 19/08/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amrubicin
1
Anthracyclines
5
Azacitidine
3
Bendamustine
1
Bleomycin
5
Bortezomib
2
Busulfan
5
Capecitabine
2
Carboplatin
3
Carmustine (BCNU)
3
Cetuximab
4
Chlorozotocin (DCNU)
1
Cisplatin
3
Crizotinib
4
Cyclophosphamide
4
Cytosine arabinoside - Aracytine - Cytarabine - Ara-C
3
Decitabine
1
Docetaxel
3
Doxorubicin - Adriamycin
3
Erlotinib
3
Etoposide
2
FOLFIRI chemotherapy regimen
1
FOLFOX chemotherapy regimen
3
Famotidine
1
Floxuridine
1
Fludarabine
3
Fluorouracil (5-FU)
3
Fotemustine
1
Gefitinib
5
Gemcitabine
5
Gemtuzumab
1
Hydroxyurea (hydroxycarbamide)
2
Ifosfamide
2
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Irinotecan
2
Lomustine (CCNU)
3
Melphalan
3
Methotrexate
5
Mitomycin C
3
Mitoxantrone
1
Nitrogen mustard
1
Nitrosoureas (suffixes '-NU', '-mustine')
4
Oxaliplatin-based regimens
4
Paclitaxel
5
Pemetrexed
3
Platinum salts
3
Procarbazine
2
Raltitrexed
1
Taxanes
4
Temozolomide
2
Teniposide
1
Topotecan
1
Trofosfamide
1
Tyrosine kinase inhibitors (EGFR) TKI
5
Vinblastine
2
Vindesine
2
Vinorelbine
1
Zinostatin
1

Publications

Fatal diffuse alveolar damage associated with oxaliplatin administration.
Clinical colorectal cancer 2011 Sep;10;198-202 2011 Sep
Structural lung damage after chemotherapy fact or fiction?
Lung cancer (Amsterdam, Netherlands) 2010 Mar;67;306-10 2010 Mar
Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma.
Cancer chemotherapy and pharmacology 2010 Feb;65;607-10 2010 Feb
An autopsy case of acute pulmonary toxicity associated with gemcitabine.
Internal medicine (Tokyo, Japan) 2003 Oct;42;1022-5 2003 Oct
Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature.
Annals of hematology 2000 Dec;79;696-9 2000 Dec
Pulmonary drug toxicity: radiologic and pathologic manifestations.
Radiographics : a review publication of the Radiological Society of North America, Inc 2000;20;1245-59 2000
[Cytostatic pneumopathy following chemotherapy for metastasizing breast neoplasm].
Schweizerische medizinische Wochenschrift 1977 Oct 08;107;1412-7 1977 Oct 08

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