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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chemotherapy, antineoplastic

5

VI.f Hemolytic and uremic syndrome (HUS). See also under Xaf

2
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amrubicin
1
Anthracyclines
5
Azacitidine
3
Bendamustine
1
Bleomycin
5
Bortezomib
2
Busulfan
5
Capecitabine
2
Carboplatin
3
Carmustine (BCNU)
3
Cetuximab
4
Chlorozotocin (DCNU)
1
Cisplatin
3
Crizotinib
4
Cyclophosphamide
4
Cytosine arabinoside - Aracytine - Cytarabine - Ara-C
3
Decitabine
1
Docetaxel
3
Doxorubicin - Adriamycin
3
Erlotinib
3
Etoposide
2
FOLFIRI chemotherapy regimen
1
FOLFOX chemotherapy regimen
3
Famotidine
1
Floxuridine
1
Fludarabine
3
Fluorouracil (5-FU)
3
Fotemustine
1
Gefitinib
5
Gemcitabine
5
Gemtuzumab
1
Hydroxyurea (hydroxycarbamide)
2
Ifosfamide
2
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Irinotecan
2
Lomustine (CCNU)
3
Melphalan
3
Methotrexate
5
Mitomycin C
3
Mitoxantrone
1
Nitrogen mustard
1
Nitrosoureas (suffixes '-NU', '-mustine')
4
Oxaliplatin-based regimens
4
Paclitaxel
5
Pemetrexed
3
Platinum salts
3
Procarbazine
2
Raltitrexed
1
Taxanes
4
Temozolomide
2
Teniposide
1
Topotecan
1
Trofosfamide
1
Tyrosine kinase inhibitors (EGFR) TKI
5
Vinblastine
2
Vindesine
2
Vinorelbine
1
Zinostatin
1

Publications

Drug-induced thrombotic thrombocytopenic purpura successfully treated with recombinant human soluble thrombomodulin.
Internal medicine (Tokyo, Japan) 2013;52;1111-4 2013
Haemolytic uraemic syndrome associated with bleomycin, epirubicin and cisplatin chemotherapy--a case report and review of the literature.
Acta oncologica (Stockholm, Sweden) 1998;37;107-9 1998
Hemolytic uremic syndrome after high dose chemotherapy with autologous stem cell support.
Cancer 1995 Dec 01;76;2338-42 1995 Dec 01

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