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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chemotherapy, antineoplastic

5

V.f Pneumothorax

2
Last update : 13/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amrubicin
1
Anthracyclines
5
Azacitidine
3
Bendamustine
1
Bleomycin
5
Bortezomib
2
Busulfan
5
Capecitabine
2
Carboplatin
3
Carmustine (BCNU)
3
Cetuximab
4
Chlorozotocin (DCNU)
1
Cisplatin
3
Crizotinib
4
Cyclophosphamide
4
Cytosine arabinoside - Aracytine - Cytarabine - Ara-C
3
Decitabine
1
Docetaxel
3
Doxorubicin - Adriamycin
3
Erlotinib
3
Etoposide
2
FOLFIRI chemotherapy regimen
1
FOLFOX chemotherapy regimen
3
Famotidine
1
Floxuridine
1
Fludarabine
3
Fluorouracil (5-FU)
3
Fotemustine
1
Gefitinib
5
Gemcitabine
5
Gemtuzumab
1
Hydroxyurea (hydroxycarbamide)
2
Ifosfamide
2
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Irinotecan
2
Lomustine (CCNU)
3
Melphalan
3
Methotrexate
5
Mitomycin C
3
Mitoxantrone
1
Nitrogen mustard
1
Nitrosoureas (suffixes '-NU', '-mustine')
4
Oxaliplatin-based regimens
4
Paclitaxel
5
Pemetrexed
3
Platinum salts
3
Procarbazine
2
Raltitrexed
1
Taxanes
4
Temozolomide
2
Teniposide
1
Topotecan
1
Trofosfamide
1
Tyrosine kinase inhibitors (EGFR) TKI
5
Vinblastine
2
Vindesine
2
Vinorelbine
1
Zinostatin
1

Publications

Clinico-radiologic features of pleuroparenchymal fibroelastosis in children.
Pediatric radiology 2019 Aug;49;1163-1170 2019 Aug
Chemotherapy-induced Spontaneous Pneumothorax: Case Series.
Acta medica Indonesiana 2016 Apr;48;134-8 2016 Apr
Spontaneous pneumothorax after intensive chemotherapy in endometrial cancer: a rare complication.
Taiwanese journal of obstetrics & gynecology 2014 Jun;53;245-7 2014 Jun
Chemotherapy-induced secondary pneumothorax.
Archivos de bronconeumologia 2014 Jan;50;44 2014 Jan
[A case of intractable pneumothorax in a patient with pulmonary adenocarcinoma during bevacizumab-containing chemotherapy].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2011 Sep;49;702-6 2011 Sep
[Clinical analysis of 12 cases of pneumothorax during intensive chemotherapy for malignant neoplasms].
Gan to kagaku ryoho. Cancer & chemotherapy 2010 Aug;37;1519-23 2010 Aug
Spontaneous pneumothorax during chemotherapy: a case report.
Onkologie 2010;33;527-30 2010
Fatal pulmonary toxicity in testis cancer with bleomycin-containing chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Aug 10;25;3543-4 2007 Aug 10
Extensive pneumothorax, pneumomediastinum and surgical emphysema as a complication of bleomycin therapy.
Pediatric radiology 2005 Dec;35;1227-9 2005 Dec
Upper lobe pulmonary fibrosis associated with high-dose chemotherapy containing BCNU for bone marrow transplantation.
Mayo Clinic proceedings 2003 May;78;630-4 2003 May
Spontaneous pneumothorax complicating chemotherapy for metastatic seminoma. A case report and a review of the literature.
Cancer 1995 Jun 01;75;2710-3 1995 Jun 01
Pneumothorax following induction chemotherapy in patients with lung metastases: a case report and literature review.
Annals of oncology : official journal of the European Society for Medical Oncology 1992 Apr;3;297-300 1992 Apr
Pneumothorax following cytotoxic chemotherapy in malignant lymphoma.
Chest 1990 Dec;98;1512-3 1990 Dec
Spontaneous pneumothorax following regression of pulmonary metastases.
The European respiratory journal 1990 Apr;3;485-6 1990 Apr
Fatal pneumothorax following bleomycin and other cytotoxic drugs.
Cancer treatment reports 1985 Mar;69;344-5 1985 Mar

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