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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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  • Drugs
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Beta-blockers

5

IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

3

Can be fatal in minutes

Last update : 17/11/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acebutolol
2
Atenolol
1
Betaxolol
2
Carvedilol
2
Celiprolol
1
Labetalol
1
Metipranolol
1
Metoprolol
1
Nadolol
1
Oxprenolol
1
Pindolol
1
Practolol
3
Propranolol
3
Sotalol
1
Timolol
2

Publications

Mechanisms of adverse effects of {beta}-agonists in asthma.
Thorax 2009 Sep;64;739-41 2009 Sep
An unusual death in an asthmatic patient.
The American journal of forensic medicine and pathology 2003 Sep;24;271-2 2003 Sep
[Side effects of drugs on the respiratory tract: experiences of the Swiss Drug Monitoring Center from 1991 to 1995].
Praxis 1996 Oct 29;85;1394-7 1996 Oct 29
Propranolol is contraindicated in asthma.
BMJ (Clinical research ed.) 1996 Dec 07;313;1486 1996 Dec 07

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