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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Oxprenolol
1
See also under beta-blockers
Last update :
07/09/2012
II - Pulmonary edema - Acute lung injury - ARDS
II.a
Pulmonary edema, noncardiogenic (NCPE)
1
IV - Airway involvement
IV.a
Bronchospasm - Wheezing - Asthma
1
IV.f
Severe or catastrophic bronchospasm or asthma attack (can be fatal)
1
V - Pleural and/or pericardial involvement
V.c
Pleural thickening
1
XII - Cardiovascular involvement / toxicity
XII.m
Cardiac- cardiorespiratory/pulmonary arrest
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Beta-blockers
