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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Barotrauma
5
Last update :
29/10/2013
II - Pulmonary edema - Acute lung injury - ARDS
II.g
Negative pressure pulmonary edema (NPPE)
3
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.a
Alveolar hemorrhage (AH), diffuse AH (DAH)
2
V - Pleural and/or pericardial involvement
V.f
Pneumothorax
4
VII - Mediastinal involvement
VII.h
Pneumomediastinum
1
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.k
Submucosal airway petechiae/hemorrhage
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Forceful inspiration against a closed glottis or airway
Mechanical ventilation (invasive)
Mechanical ventilation (noninvasive)
