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Alendronate - Alendronic acid

Alendronate may cause severe laryngotracheal injury following pill aspiration into the aiway, representing pill- rather or as opposed to true drug-induced respiratory disease.

Last update : 19/02/2022

IV.s Lolalized airway inflammation/burgeoning/stenosis: The pill aspiration syndrome

VIII.d Thermal (burns, frostbite), chemical or caustic injury on the face, mouth, tongue, pharynx or upper airway

VIII.ad Osteonecrosis of the jaw

X.b Antiphospholipid antibodies w/wo the APL syndrome

XI.i Esophageal toxicity

XI.o Dysphagia

XV.bh Path: Foreign body reaction in large airway walls

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France