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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Alendronate - Alendronic acid

2

VIII.ad Osteonecrosis of the jaw

2
Last update : 19/01/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biphosphonates
2
Iron pill (aspirated)
2
Pill (aspirated)
2

Publications

Osteonecrosis of the jaw in a Crohn's disease patient following a course of Bisphosphonate and Adalimumab therapy: a case report.
BMC gastroenterology 2014 Jan 08;14;6 2014 Jan 08

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