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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Alendronate - Alendronic acid

2

IV.s Lolalized airway inflammation/burgeoning/stenosis: The pill aspiration syndrome

1
Last update : 29/09/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biphosphonates
2
Iron pill (aspirated)
2
Pill (aspirated)
2

Publications

Evaluation and management of pill aspiration: case discussion and review of the literature.
Chest 2013 Jun;143;1791-1795 2013 Jun
Severe airway injury due to alendronate aspiration.
Canadian respiratory journal 2013;20;410-2 2013

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