Pneumotox » Drug » Acetazolamide

Acetazolamide

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Last update : 31/12/2014

II.a Pulmonary edema, noncardiogenic (NCPE)

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IX.a Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

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X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

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XI.d Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

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XII.n Cardiovascular collapse - Cardiogenic shock - Hypotension

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XXI.a Rechallenge can lead to near-fatal or fatal relapse of AE/ILD

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XXI.b Rechallenge can lead to relapse of AE/ILD

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Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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