Pneumotox » Drug » Acetazolamide » XXI.a - Rechallenge can lead to near-fatal or fatal relapse of AE/ILD

Acetazolamide

Last update : 13/07/2024

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment