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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Acetazolamide

3

II.a Pulmonary edema, noncardiogenic (NCPE)

2
Last update : 06/07/2024
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Acetazolamide-induced pulmonary oedema: A disproportionality analysis from the EudraVigilance database.
British journal of clinical pharmacology 2024 Jul;90;1751-1755 2024 Jul
Acetazolamide induced noncardiogenic pulmonary edema, an underreported serious adverse event.
American journal of ophthalmology case reports 2023 Jun;30;101827 2023 Jun
A case of non-cardiogenic pulmonary edema provoked by intravenous acetazolamide.
Acute medicine & surgery 2017 Jul;4;349-352 2017 Jul
Acute pulmonary oedema due to single dose acetazolamide taken after cataract surgery.
BMJ case reports 2016 May 11;2016; 2016 May 11
Recurrent shock and pulmonary edema due to acetazolamide medication after cataract surgery.
Heart & lung : the journal of critical care 2014;43;124-6 2014
Acute pulmonary edema after a single oral dose of acetazolamide.
Hippokratia 2013 Apr;17;177-9 2013 Apr
Anaphylactic shock and acute pulmonary edema after a single oral dose of acetazolamide.
The American journal of emergency medicine 2002 Jul;20;371-2 2002 Jul

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