Pneumotox » Drug » Palytoxin (a potent zoanthid marine coral toxin)

Palytoxin (a potent zoanthid marine coral toxin)

Poisoning may occur via the dermal, oral or inhaled route, followowing seawater aquarium tank management, maintenance, cleaning and/or contact with contaminated marine fish

Last update : 12/11/2017

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

I.b Pneumonitis (ILD)

II.b ARDS - Acute lung injury

IV.a Bronchospasm - Wheezing - Asthma

VI.i Acute pulmonary hypertension

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

X.j Myopathy-Myositis-Polymyositis (see also under Xba)

XI.ay Chest tightness

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

XII.ai Cardiotoxicity

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France