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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Palytoxin (a potent zoanthid marine coral toxin)

2

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

1
Last update : 12/11/2017
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Palytoxin congeners.
Archives of toxicology 2018 Jan;92;143-156 2018 Jan
Hyperkalemia, hyperphosphatemia, acute kidney injury, and fatal dysrhythmias after consumption of palytoxin-contaminated goldspot herring.
Annals of emergency medicine 2014 Dec;64;633-6 2014 Dec

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