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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Palytoxin (a potent zoanthid marine coral toxin)
2
X.j
Myopathy-Myositis-Polymyositis (see also under Xba)
1
Last update :
07/11/2016
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications
Rhabdomyolysis and myocardial damage induced by palytoxin, a toxin of blue humphead parrotfish.