Back

The Drug-Induced Respiratory Disease Website and App

Transhepatic arterial chemoembolization (TACE)

Transhepatic Arterial Chemo-Embolizatiion(for the treatment of HCC (PMID 9599386, 24607940). See also under acrylate/methacrylate, lipiodol, 90-Yttrium beads, and adriamycin/doxorubicin. Injected material may shunt through the pulmonary vasculature andaccess the lung and brain causing acute pulmonary and/or CNS complications (PMID 21036627, 27904836)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Interstitial/parenchymal lung disease

I.b

Pneumonitis (interstitial lung disease/ILD)
I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
I.d

Organizing pneumonia pattern (an area or areas of consolidation on imaging)
I.e

Acute eosinophilic pneumonia (AEP)
I.j

Exogenous lipoid pneumonia (subacute, acute)
I.y

Progression, acceleration or exacerbation of preexisting ILD/fibrosis
I.z

An area or areas of consolidation

II - Pulmonary edema - Acute lung injury - ARDS

II.b

ARDS - Acute lung injury

V - Pleural and/or pericardial involvement

V.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

VI - Pulmonary vasculopathy

VI.a

Pulmonary embolism - Venous thrombosis/thromboembolism
VI.e

Fat/oil embolism - The FES embolism syndrome
VI.v

Foreign body/substance pulmonary embolism
VI.aa

Lipiodol pulmonary embolism

XI - Miscellaneous

XI.aa

CNS symptoms or involvement, stroke

XV - Pathology

XV.c

Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

XVI - Imaging

XVI.s

Imaging: An area or areas of involvement with high attenuation numbers or metallic density

XVIII - Distinctive patterns - 'Eye-catchers'

XVIII.h

Eye-catcher: Lipiodol embolism