The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

No all BOOP cases were documented pathologically

Publications

Shogbon AO, Hap J, Dretler R, Dalvi AG

Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer.

Journal of pharmacy practice 2013 Feb;26;62-6 — 2013 Feb — 62-6

Dahlqvist C, Fremault A, Carrasco J, Colinet B

[Obliterative bronchiolitis with organising pneumonia following FOLFOX 4 chemotherapy].

Revue des maladies respiratoires 2010;27;84-7 — 2010 — 84-7

Trisolini R, Lazzari Agli L, Tassinari D, Rondelli D, Cancellieri A, Patelli M, Falcone F, Poletti V

Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.

The European respiratory journal 2001 Jul;18;243-5 — 2001 Jul — 243-5