Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website and App

Organomercurials (Methyl- ethyl-mercury)

Organomercurials are supertoxicants that mainly target the brain and cerebellum, not the lung. They are liste here to avoid unecessary exposure that can be fatal. Any vial containing such products must be handled by specialized personel. Organomercurials can cross latex gloves and penetrate the dermis, sometimes causing irreversible and ultimately fatal cerebellar dysfunction and death within a few months (PMID 9614528)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVIII - Neuromuscular / CNS involvement - Disordered breathing (during sleep)