The Drug-Induced Respiratory Disease Website and App

Vedolizumab

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Interstitial/parenchymal lung disease

I.a

Pneumonitis (interstitial lung disease/ILD)

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

I.l

Lung nodule or nodules

XLI - Pulmonary edema - Acute lung injury - ARDS

XLI.e

ARDS - Acute lung injury

XLIII - Airway involvement

XLIII.x

Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

XLIV - Central-large-upper airway (incl. pharyngeal-nasal) involvement

XLIV.ap

Bronchorrhea

XLIX - Systemic/Distant conditions, syndromes and reactions

XLIX.i

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

XLIX.q

Neutrophilic dermatosis (Pyoderma, Sweet syndrome)

LV - Imaging

LV.g

Imaging: Diffuse whiteout/alveolar shadowing (see also under IIb-ARDS)

LV.v

Imaging: Centrilobular micronodules (can be diffuse)

LVIII - Pathology

LVIII.b

Path: Eosinophilic pneumonia (subacute or acute) (see also Ic)

LVIII.d

Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

LVIII.f

Path: ILD with a granulomatous component (see also Im)

LVIII.h

Path: Pulmonary necrotizing granuloma with neutrophilic microabscesses

LVIII.al

Path: Acute/subacute bronchiolitis (see also IVc, IVi)

LIX - Infections & related conditions

LIX.a

Respiratory tract infection incl. pneumonia

LIX.u

Strongyloides stercoralis hyperinfection (w/wo DAH)

LXII - Rechallenge data

LXII.b

Rechallenge can lead to relapse of AE/ILD