The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.c

Pleural thickening - Fibrothorax

Publications

Ito T, Koyama S, Iwamoto S, Hirayama M, Azuma E

Acquired Platythorax, or Anteroposterior Flattening of the Chest Wall, as a Late Complication of Cyclophosphamide Treatment for Childhood Acute Lymphoblastic Leukemia, Presenting in a Young Man with Respiratory Failure.

The American journal of case reports. 2018;19:1317-1323

von der Thüsen JH, Hansell DM, Tominaga M, Veys PA, Ashworth MT, Owens CM, Nicholson AG

Pleuroparenchymal fibroelastosis in patients with pulmonary disease secondary to bone marrow transplantation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2011;24(12):1633-9

Hamada K, Nagai S, Kitaichi M, Jin G, Shigematsu M, Nagao T, Sato A, Mishima M

Cyclophosphamide-induced late-onset lung disease.

Internal medicine (Tokyo, Japan). 2003;42(1):82-7

Malik SW, Myers JL, DeRemee RA, Specks U

Lung toxicity associated with cyclophosphamide use. Two distinct patterns.

American journal of respiratory and critical care medicine. 1996;154(6 Pt 1):1851-6

Santamauro JT, Stover DE, Jules-Elysee K, Maurer JR

Lung transplantation for chemotherapy-induced pulmonary fibrosis.

Chest. 1994;105(1):310-2

Stentoft J

Progressive pulmonary fibrosis complicating cyclophosphamide therapy.

Acta medica Scandinavica. 1987;221(4):403-7