The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary embolism - Venous thrombosis/thromboembolism
In the context of the so-called heparin-induced thrombocytopenia. Thromboembolism may predate thrombocytopenia
Publications
Fatal Pulmonary Embolism Secondary to Heparin-Induced Thrombocytopenia in Hemodialysis: A Case Study.
Hemodialysis international. International Symposium on Home Hemodialysis 2026 Jan;30 — 2026 Jan — 288-290
A "Catastrophic" Heparin-Induced Thrombocytopenia.
Case reports in medicine 2020;2020;6985020 — 2020 — 6985020
Pulmonary embolism caused by delayed heparin-induced thrombocytopenia in a patient who received prophylactic LMWH.
The American journal of case reports 2012;13;118-21 — 2012 — 118-21
Heparin-induced thrombocytopenia (HIT) causing portosplenic, superior mesenteric, and splenic vein thrombosis resulting in splenic rupture and pulmonary emboli formation.
Clinical imaging 2012 Nov-Dec;36;865-8 — 2012 Nov-Dec — 865-8
Heparin-induced thrombocytopenia associated with pulmonary embolism.
Clinical cardiology 2010 Feb;33;E65-7 — 2010 Feb — E65-7
Clinical practice. Heparin-induced thrombocytopenia.
The New England journal of medicine 2006 Aug 24;355;809-17 — 2006 Aug 24 — 809-17
Risk of thrombosis in patients with malignancy and heparin-induced thrombocytopenia.
American journal of hematology 2004 Jul;76;240-4 — 2004 Jul — 240-4