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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.h

Cement embolism

Typically, the condition closely follows percutaneous vertebroplasty and cement can be visualized on unenhanced CT

Publications

Huang WC, Lee P, Ling Wong TG, Tiong Tan JK, Hwang NC

Diagnosis of bone cement implantation syndrome using point of care ultrasound examination.

Annals of cardiac anaesthesia. 2021;24(3):372-374

Chevallier M, Chevallier-Lugon C, Friedlaender A, Addeo A

Vertebral Metastasis Treated by Vertebroplasty, a Cause of Respiratory Failure: Case Report and Literature Review.

Case reports in oncology. 2021;14(1):279-283

Fadili Hassani S, Cormier E, Shotar E, Drir M, Spano JP, Morardet L, Collet JP, Chiras J, Clarençon F

Intracardiac cement embolism during percutaneous vertebroplasty: incidence, risk factors and clinical management.

European radiology. 2019;29(2):663-673

Sastre JA, López T, Dalmau MJ, Cuello RE

Bone cement implantation syndrome during spinal surgery requiring cardiac surgery.

A & A case reports. 2013;1(6):82-5

Chen CY, Cheng WE, Lin CH, Chen SC, Shih CM

Tadpoles in the lungs. Cement pulmonary embolism complicating vertebroplasty of spinal metastasis.

American journal of respiratory and critical care medicine. 2014;190(3):340-1

Huh S, Lee H

Pulmonary bone cement embolism: CT angiographic evaluation with material decomposition using gemstone spectral imaging.

Korean journal of radiology. 2014;15(4):443-7

Rothermich MA, Buchowski JM, Bumpass DB, Patterson GA

Pulmonary cement embolization after vertebroplasty requiring pulmonary wedge resection.

Clinical orthopaedics and related research. 2014;472(5):1652-7

Zheng N, Liang M, Zhang HD, Zhu SH, Yang TT, Zhuo L, Wang GF, Liu HX, Liu L

Fatal extensive bone cement embolism: histological findings confirmed by Fourier transform infrared spectroscopy.

Forensic science international. 2013;229(1-3):e23-5

Sifuentes Giraldo WA, Lamúa Riazuelo JR, Gallego Rivera JI, Vázquez Díaz M

Cement pulmonary embolism after vertebroplasty.

Reumatologia clinica. 2013;9(4):239-42

Bach AG, Restrepo CS, Abbas J, Villanueva A, Lorenzo Dus MJ, Schöpf R, Imanaka H, Lehmkuhl L, Tsang FH, Saad FF, Lau E, Rubio Alvarez J, Battal B, Behrmann C, Spielmann RP, Surov A

Imaging of nonthrombotic pulmonary embolism: biological materials, nonbiological materials, and foreign bodies.

European journal of radiology. 2013;82(3):e120-41

Schulz C, Efinger K, Schwarz W, Mauer UM

[Experiences with cement leakage after balloon kyphoplasty].

Der Orthopade. 2012;41(11):881-8

Chick JF, Chauhan NR, Mullen KM, Bair RJ, Khurana B

Pulmonary cement emboli after kyphoplasty.

Internal and emergency medicine. 2012;7(6):569-71

Tonolini M, Bianco R

Pulmonary cement embolism after pedicle screw vertebral stabilization.

Journal of emergencies, trauma, and shock. 2012;5(3):272-3

Chung JW, Shin JK, Chee HK, Kim JS, Kim DC, Park JB

Removal of Bone Cement through Right Anterolateral Thoracotomy.

The Korean journal of thoracic and cardiovascular surgery. 2012;45(3):202-4

Tourtier JP, Cottez S

Images in clinical medicine. Pulmonary cement embolism after vertebroplasty.

The New England journal of medicine. 2012;366(3):258

Luetmer MT, Bartholmai BJ, Rad AE, Kallmes DF

Asymptomatic and unrecognized cement pulmonary embolism commonly occurs with vertebroplasty.

AJNR. American journal of neuroradiology. 2011;32(4):654-7

Fornell-Pérez R, Santana-Montesdeoca JM, Junquera-Rionda P

[Multiple pulmonary embolisms caused by acrylic cement after vertebroplasty].

Archivos de bronconeumologia. 2010;46(9):493-4

Venmans A, Klazen CA, Lohle PN, van Rooij WJ, Verhaar HJ, de Vries J, Mali WP

Percutaneous vertebroplasty and pulmonary cement embolism: results from VERTOS II.

AJNR. American journal of neuroradiology. 2010;31(8):1451-3

Bachmeyer C, Wislez M, Khalil A

[Multiple pulmonary embolism of cement after vertebroplasty].

Presse medicale (Paris, France : 1983). 2010;39(3):406-7

Favrolt N, Bonniaud P, Cercueil JP, Logerot S, Foucher P, Camus C, Camus P

[Pulmonary embolism by cyanoacrylate following embolisation of an arteriovenous malformation].

Revue des maladies respiratoires. 2009;26(1):74-7

Abdul-Jalil Y, Bartels J, Alberti O, Becker R

Delayed presentation of pulmonary polymethylmethacrylate emboli after percutaneous vertebroplasty.

Spine. 2007;32(20):E589-93

Schneider L, Plit M

Pulmonary embolization of acrylic cement during percutaneous vertebroplasty.

Internal medicine journal. 2007;37(6):423-5

Baumann A, Tauss J, Baumann G, Tomka M, Hessinger M, Tiesenhausen K

Cement embolization into the vena cava and pulmonal arteries after vertebroplasty: interdisciplinary management.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2006;31(5):558-61

Barragán-Campos HM, Vallée JN, Lo D, Cormier E, Jean B, Rose M, Astagneau P, Chiras J

Percutaneous vertebroplasty for spinal metastases: complications.

Radiology. 2006;238(1):354-62